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Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019

Guohua Chen, Wen Su, Jiayao Yang, Dan Luo, Ping Xia, Wen Jia, Xiuyang Li, Chuan Wang, Suping Lang, Qingbin Meng, Ying Zhang, Yuhe Ke, An Fan, Shuo Yang, Yujiao Zheng, Xuepeng Fan, Jie Qiao, Fengmei Lian, Li Wei, Xiaolin Tong

《医学前沿（英文）》 2020年 第14卷 第6期   页码 752-759 doi: 10.1007/s11684-020-0813-6

摘要： This study aimed to evaluate the efficacy of Chinese herbal medicine (CHM) in patients with severe/critical coronavirus disease 2019 (COVID-19). In this retrospective study, data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20, 2020. All patients were divided into an exposed group (CHM users) and a control group (non-users). After propensity score matching in a 1:1 ratio, 156 CHM users were matched by propensity score to 156 non-users. No significant differences in seven baseline clinical variables were found between the two groups of patients. All-cause mortality was reported in 13 CHM users who died and 36 non-users who died. After multivariate adjustment, the mortality risk of CHM users was reduced by 82.2% (odds ratio 0.178, 95% CI 0.076–0.418; <0.001) compared with the non-users. Secondly, age (odds ratio 1.053, 95% CI 1.023–1.084; <0.001) and the proportion of severe/critical patients (odds ratio 0.063, 95% CI 0.028–0.143; <0.001) were the risk factors of mortality. These results show that the use of CHM may reduce the mortality of patients with severe/critical COVID-19.

关键词： COVID-19     CHM     mortality     a retrospective cohort study    

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Organ function support in patients with coronavirus disease 2019: Tongji experience

Yong Li, Fan He, Ning Zhou, Jia Wei, Zeyang Ding, Luyun Wang, Peng Chen, Shuiming Guo, Binhao Zhang, Xiaoning Wan, Wei Zhu, on behalf of Multidisciplinary Team for COVID-19, Optical Valley Branch of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China

《医学前沿（英文）》 2020年 第14卷 第2期   页码 232-248 doi: 10.1007/s11684-020-0774-9

摘要： Coronavirus disease 2019 (COVID-19) is a highly contagious disease and a serious threat to human health. COVID-19 can cause multiple organ dysfunction, such as respiratory and circulatory failure, liver and kidney injury, gastrointestinal dysfunction, disseminated intravascular coagulation, and thromboembolism, and even death. The World Health Organization reports that the mortality rate of severe-type COVID-19 is over 50%. Currently, the number of severe cases worldwide has increased rapidly, but the experience in the treatment of infected patients is still limited. Given the lack of specific antiviral drugs, multi-organ function support treatment is important for patients with COVID-19. To improve the cure rate and reduce the mortality of patients with severe- and critical-type COVID-19, this paper summarizes the experience of organ function support in patients with severe- and critical-type COVID-19 in Optical Valley Branch of Tongji Hospital, Wuhan, China. This paper systematically summarizes the procedures of functional support therapies for multiple organs and systems, including respiratory, circulatory, renal, gastrointestinal, hepatic, and hematological systems, among patients with severe- and critical-type COVID-19. This paper provides a clinical reference and a new strategy for the optimal treatment of COVID-19 worldwide.

关键词： COVID-19     severe and critical type     organ function support    

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Treatment of severe acute pancreatitis through retroperitoneal laparoscopic drainage

Chun Tang, Baolin Wang, Bing Xie, Hongming Liu, Ping Chen

《医学前沿（英文）》 2011年 第5卷 第3期   页码 302-305 doi: 10.1007/s11684-011-0145-7

摘要： A treatment method based on drainage via retroperitoneal laparoscopy was adopted for 15 severe acute pancreatitis (SAP) patients to investigate the feasibility of the method. Ten patients received only drainage via retroperitoneal laparoscopy, four patients received drainage via both retroperitoneal and preperitoneal laparoscopy, and one patient received drainage via conversion to laparotomy. Thirteen patients exhibited a good drainage effect and were successfully cured without any other surgical treatment. Two patients had encapsulated effusions or pancreatic pseudocysts after surgery, but were successfully cured after lavage and B ultrasound-guided percutaneous catheter drainage. SAP treatment via retroperitoneal laparoscopic drainage is an effective surgical method, resulting in minor injury.

关键词： severe acute pancreatitis (SAP)     laparoscope     retroperitoneal drainage     treatment    

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Experience gained in analyzing severe accidents for WWER RP using CC SOCRAT

《能源前沿（英文）》 2021年 第15卷 第4期   页码 872-886 doi: 10.1007/s11708-021-0796-2

摘要： The current Russian regulatory documents on the safety of nuclear power plant (NPP) specify the requirements regarding design basis accidents (DBAs) and beyond design basis accidents (BDBAs), including severe accidents (SAs) with core meltdown, in NPP design (NP-001-15, NP-082-07, and others). For a rigorous calculational justification of BDBAs and SAs, it is necessary to develop an integral CC that will be in line with the requirements of regulatory documents on verification and certification (RD-03-33-2008, RD-03-34-2000) and will allow for determining the amount of data required to provide information within the scope stipulated by the requirements for the structure of the safety analysis report (SAR) (NP-006-16). The system of codes for realistic analysis of severe accidents (SOCRAT) (formerly, thermohydraulics (RATEG)/coupled physical and chemical processes (SVECHA)/behavior of core materials relocated into the reactor lower plenum (HEFEST)) was developed in Russia to analyze a wide range of SAs at NPP with water-cooled water-moderated power-generating reactor (WWER) at all stages of the accident. Enhancements to the code and broadening of its applicability are continually being pursued by the code developers (Nuclear Safety Institute of the Russian Academy of Sciences (IBRAE RAN)) with OKB Gidropress JSC and other organizations. Currently, the SOCRAT/1 code can be used as a base tool to obtain realistic estimates for all parameters important for computational justification of the reactor plant (RP) safety at the in-vessel stage of SAs with fuel melting. To perform analyses using CC SOCRAT/1, the experience gained during execution of thermohydraulic codes is applied, which allows for minimizing the uncertainties in the results at the early stage of an accident scenario. This study presents the results of the work performed in 2010–2020 in OKB Gidropress JSC using the CC SOCRAT/1. Approaches have been considered to develop calculational models and analyze SAs using CC SOCRAT. This process, which is clearly structured in OKB Gidropress JSC, provides a noticeable reduction in human involvement, and reduces the probability of erroneous results.

关键词： system of codes for realistic analysis of severe accidents (SOCRAT)     design basis accidents (DBAs)     severe accidents (SAs)     computer code (CC)     nuclear power plant (NPP) design     water-cooled water-moderated (WWER)     modeling     model     safety requirements    

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Outcomes of haploidentical bone marrow transplantation in patients with severe aplastic anemia-II thatprogressed from non-severe acquired aplastic anemia

《医学前沿（英文）》 2021年 第15卷 第5期   页码 718-727 doi: 10.1007/s11684-020-0807-4

摘要： Severe aplastic anemia II (SAA-II) progresses from non-severe aplastic anemia (NSAA). The unavailability of efficacious treatment has prompted the need for haploidentical bone marrow transplantation (haplo-BMT) in patients lacking a human leukocyte antigen (HLA)-matched donor. This study aimed to investigate the efficacy of haplo-BMT for patients with SAA-II. Twenty-two patients were included and followed up, and FLU/BU/CY/ATG was used as conditioning regimen. Among these patients, 21 were successfully engrafted, 19 of whom survived after haplo-BMT. Four patients experienced grade II–IV aGvHD, including two with grade III–IV aGvHD. Six patients experienced chronic GvHD, among whom four were mild and two were moderate. Twelve patients experienced infections during BMT. One was diagnosed with post-transplant lymphoproliferative disorder and one with probable EBV disease, and both recovered after rituximab infusion. Haplo-BMT achieved 3-year overall survival and disease-free survival rate of 86.4%±0.73% after a median follow-up of 42 months, indicating its effectiveness as a salvage therapy. These promising outcomes may support haplo-BMT as an alternative treatment strategy for patients with SAA-II lacking HLA-matched donors.

关键词： severe aplastic anemia     non-severe acquired aplastic anemia     haploidentical bone marrow transplantation     outcomes    

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with composition of lung microbiota and important taxa predicting clinical prognosis in patients with severe

《医学前沿（英文）》 2022年 第16卷 第3期   页码 389-402 doi: 10.1007/s11684-021-0856-3

摘要： Few studies have described the key features and prognostic roles of lung microbiota in patients with severe community-acquired pneumonia (SCAP). We prospectively enrolled consecutive SCAP patients admitted to ICU. Bronchoscopy was performed at bedside within 48 h of ICU admission, and 16S rRNA gene sequencing was applied to the collected bronchoalveolar lavage fluid. The primary outcome was clinical improvements defined as a decrease of 2 categories and above on a 7-category ordinal scale within 14 days following bronchoscopy. Sixty-seven patients were included. Multivariable permutational multivariate analysis of variance found that positive bacteria lab test results had the strongest independent association with lung microbiota (R2=0.033; P=0.018), followed by acute kidney injury (AKI; R2=0.032; P=0.011) and plasma MIP-1β level (R2=0.027; P=0.044). Random forest identified that the families Prevotellaceae, Moraxellaceae, and Staphylococcaceae were the biomarkers related to the positive bacteria lab test results. Multivariable Cox regression showed that the increase in α-diversity and the abundance of the families Prevotellaceae and Actinomycetaceae were associated with clinical improvements. The positive bacteria lab test results, AKI, and plasma MIP-1β level were associated with patients’ lung microbiota composition on ICU admission. The families Prevotellaceae and Actinomycetaceae on admission predicted clinical improvements.

关键词： severe community-acquired pneumonia     lung microbiota     clinical improvements     7-category ordinal scale     Prevotellaceae    

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Clinical manifestations and outcomes in severe ulcerative colitis

YANG Xuesong, YAO Wei, LIU Wenbin, LI Jun, LU Yumin

《医学前沿（英文）》 2007年 第1卷 第2期   页码 192-195 doi: 10.1007/s11684-007-0036-0

摘要： In order to evaluate the clinical manifestations and outcomes of severe ulcerative colitis (UC), we retrospectively reviewed 41 patients with severe UC from 144 consecutively hospitalized UC cases from 1988 to 2004. Data recorded included onset, symptoms, signs, laboratory results, endoscopic, radiologic and pathologic findings, the clinical treatment process and follow-up. Of these severe cases, 92.7% (38/41) had pancolitis. Clinically, 36.9% (15/41) were categorized as first onset type, 36.9% (15/41) were chronic persistent and 26.8% (11/41) were chronic recurrent. Steroids played a main role in the remission of severe UC (61.0%). Thirty-one cases (75.6%) were relieved by drug therapy. Seven cases (17.1%) progressed to the need for operation. An early age of onset, pancolitis, low hemoglobin and serum albumin levels, and the need for intravenous steroids tended to be associated with the need for surgery. In conclusion, most of the severe UC patients respond well to drug therapy, but for individuals who are unresponsive to drug therapy, or for those depending on steroids, after a reasonable duration of treatment, the necessity for surgery should be considered.
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突发性灾害天气的结构预测与应急对策

欧阳首承,谢娜,郝丽萍

《中国工程科学》 2005年 第7卷 第9期   页码 9-13

摘要：

以V-3θ图的非规则信息结构分别分析了北京2004年7月10日和上海7月12日出现的突发性强对流降水、风暴和川东北的区域性特大暴雨天气过程的结构特征，并简单地讨论了突发灾害天气的预测原理和分析、预测方法。结果表明，局地强对流降水天气或区域性大暴雨在V-3θ图的结构上事先有明显的征兆而可预测；并作为有效的防灾、减灾和相应城市建设应考虑的排水、储水和防风等的特殊性应急措施。

关键词： 溃变     结构分析     突发性强对流     防灾措施    

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Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in

《医学前沿（英文）》 2022年 第16卷 第6期   页码 969-974 doi: 10.1007/s11684-021-0912-z

摘要： Malaria is highly prevalent in Nigeria and accounts for approximately 40% of global malaria mortality. However, most reports on severe malaria in Nigeria are from hospital-based studies without accurate information from communities; thus, malaria-related deaths in the community are left untracked. This study aimed to describe the prevalence and pattern of severe malaria in a community in Northwestern Nigeria. A cross-sectional study was conducted among 2–10-year-old children in Sokoto, in August and December 2016, to determine the endemicity of malaria based on Plasmodium falciparum prevalence rate (PfPR2-10) and to describe the disease pattern. Severe malaria was diagnosed according to the World Health Organisation criteria. Data were described using Stata version 15. The prevalence of non-anaemia severe malaria was higher than expected (2.6%), considering the endemicity pattern which was mesoendemic based on a PfPR2-10 of 34.8%. The mean age of children with severe malaria was 3.73 years, and the male–female ratio was 2:1. However, 54.0% of the patients had hyperparasitaemia. A relatively high prevalence of non-anaemia severe malaria was found in Wamakko. This finding suggests the need to identify and treat cases in the community using modifications of current strategies, particularly seasonal malaria chemoprophylaxis.

关键词： severe malaria     nigeria     malaria mortality     PfPR2-10     intermediate malaria transmission    

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A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus

《医学前沿（英文）》 doi: 10.1007/s11684-023-1011-0

摘要： We aimed to investigate the safety and efficacy of nirmatrelvir/ritonavir (Paxlovid) therapy for hemodialysis-dependent patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Thirteen hemodialysis patients infected with the Omicron variant of SARS-CoV-2 from April 3 to May 30, 2022, were recruited. Laboratory parameters and chest CT (computed tomography) imaging were analyzed. The treatment group included six patients who received 150 mg/100 mg of Paxlovid orally once daily for 5 days, whereas the control group included seven patients who received basic treatment. No serious adverse reactions or safety events were recorded. Four control patients progressed to moderate disease, and none in the treatment group showed progression of chest CT findings (P < 0.05). Paxlovid therapy tended toward early viral clearance and low viral load on Day 8. Moreover, 83.3% of the patients in the treatment group and 57.1% of the patients in the control group turned negative within 22 days. In the Paxlovid treatment group, we found significantly increased levels of lymphocytes (P=0.03) and eosinophils (P=0.02) and decreased levels of D-dimer on Day 8 compared with those on Day 1. Paxlovid therapy showed a potential therapeutic effect with good tolerance in hemodialysis patients. The optimal dose and effectiveness evaluation must be further investigated in a largeer cohort.

关键词： Paxlovid     hemodialysis     SARS-CoV-2     viral load     chest CT scan    

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压水堆熔融物堆内滞留策略：历史回顾与研究展望 Review

马卫民,元一单,Bal Raj Sehgal

《工程（英文）》 2016年 第2卷 第1期   页码 103-111 doi: 10.1016/J.ENG.2016.01.019

摘要：

本文对广泛应用于第三代压水堆的严重事故缓解措施——熔融物堆内滞留(IVR)进行了历史回顾。IVR策略最早源自于第二代反应堆Lovissa VVER-440的改进设计，以应对堆芯熔化事故。随后，IVR策略被应用于许多新设计的反应堆，如西屋的AP1000、韩国的APR1400以及中国的先进压水堆CAP1400和华龙一号。对IVR策略有效性影响最大的因素分别为堆内堆芯熔化进程、熔融物加载于压力容器壁面的热流密度和压力容器外部冷却。对于堆芯熔化进程，过去人们一直仅关注压力容器下腔室内熔池的换热行为。但通过回顾与分析，本文认为堆内的其他现象，如堆芯的降级和迁移、碎片床的形成及其可冷却性以及熔池的动态形成过程等，可能也会对熔池的最终状态及其作用于下封头的热负荷产生影响。通过对相关研究的回顾，本文希望找出IVR策略的研究中有待完善的部分，并据目前发展水平提出未来IVR研究的需求。

关键词： 压水堆     严重事故     熔融物堆内滞留     碎片床形成     碎片床再熔化     熔池形成     熔池热工水力学     临界热流密度    

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New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

《医学前沿（英文）》 2022年 第16卷 第1期   页码 17-24 doi: 10.1007/s11684-021-0873-2

摘要： Obesity is an important risk factor of type 2 diabetes (T2D), which has become an important factor threatening human health. However, no perfect drug choice for obesity exists. Semaglutide is a kind of human glucagon-like peptide-1 (GLP-1) analog that promotes insulin secretion while inhibiting glucagon secretion through a glucose concentration-dependent mechanism. GLP-1 can also delay stomach emptying and suppress appetite to help lose weight. This review summarizes clinical evidence of the semaglutide effect on T2D and obesity and establishes expectations on future clinical trials for obesity treatment.

关键词： semaglutide     type 2 diabetes     obesity    

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Microbial biodegradation of plastics: Challenges, opportunities, and a critical perspective

《环境科学与工程前沿（英文）》 2022年 第16卷 第12期 doi: 10.1007/s11783-022-1596-6

摘要：

● Health hazards of plastic waste on environment are discussed.

关键词： Plastic-waste     Polymers     Health-hazards     Biodegradation     Microorganisms     Enzymes    

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Arsenic trioxide induced rhabdomyolysis, a rare but severe side effect, in an APL patient: a case report

null

《医学前沿（英文）》 2017年 第11卷 第2期   页码 284-286 doi: 10.1007/s11684-017-0514-y

摘要：

Arsenic trioxide (ATO), a component of the traditional Chinese medicine arsenic sublimate, promotes apoptosis and induces leukemic cell differentiation. Combined with all-trans-retinotic acid (ATRA), ATO has become the first-line induction therapy in treating acute promyelocytic leukemia (APL). The most common side effects of ATO include hepatotoxicity, gastrointestinal symptoms, water-sodium retention, and nervous system damage. In this report, we present a rare side effect, rhabdomyolysis, in a 68-year-old female APL patient who was treated with ATO. After taking 10 mg ATO daily for 6 days, she presented shortness of breath, myodynia, elevated creatine kinase, and acute renal insufficiency. This report describes the first case of ATO-induced rhabdomyolysis.

关键词： arsenic trioxide     APL     rhabdomyolysis    

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Machine learning in building energy management: A critical review and future directions

《工程管理前沿（英文）》 2022年 第9卷 第2期   页码 239-256 doi: 10.1007/s42524-021-0181-1

摘要： Over the past two decades, machine learning (ML) has elicited increasing attention in building energy management (BEM) research. However, the boundary of the ML-BEM research has not been clearly defined, and no thorough review of ML applications in BEM during the whole building life-cycle has been published. This study aims to address this gap by reviewing the ML-BEM papers to ascertain the status of this research area and identify future research directions. An integrated framework of ML-BEM, composed of four layers and a series of driving factors, is proposed. Then, based on the hype cycle model, this paper analyzes the current development status of ML-BEM and tries to predict its future development trend. Finally, five research directions are discussed: (1) the behavioral impact on BEM, (2) the integration management of renewable energy, (3) security concerns of ML-BEM, (4) extension to other building life-cycle phases, and (5) the focus on fault detection and diagnosis. The findings of this study are believed to provide useful references for future research on ML-BEM.

关键词： building energy management     machine learning     integrated framework     knowledge evolution    

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标题 作者 时间 类型 操作

Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019

Guohua Chen, Wen Su, Jiayao Yang, Dan Luo, Ping Xia, Wen Jia, Xiuyang Li, Chuan Wang, Suping Lang, Qingbin Meng, Ying Zhang, Yuhe Ke, An Fan, Shuo Yang, Yujiao Zheng, Xuepeng Fan, Jie Qiao, Fengmei Lian, Li Wei, Xiaolin Tong

期刊论文

Organ function support in patients with coronavirus disease 2019: Tongji experience

Yong Li, Fan He, Ning Zhou, Jia Wei, Zeyang Ding, Luyun Wang, Peng Chen, Shuiming Guo, Binhao Zhang, Xiaoning Wan, Wei Zhu, on behalf of Multidisciplinary Team for COVID-19, Optical Valley Branch of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China

期刊论文

Treatment of severe acute pancreatitis through retroperitoneal laparoscopic drainage

Chun Tang, Baolin Wang, Bing Xie, Hongming Liu, Ping Chen

期刊论文

Experience gained in analyzing severe accidents for WWER RP using CC SOCRAT

期刊论文

Outcomes of haploidentical bone marrow transplantation in patients with severe aplastic anemia-II thatprogressed from non-severe acquired aplastic anemia

期刊论文

with composition of lung microbiota and important taxa predicting clinical prognosis in patients with severe

期刊论文

Clinical manifestations and outcomes in severe ulcerative colitis

YANG Xuesong, YAO Wei, LIU Wenbin, LI Jun, LU Yumin

期刊论文

突发性灾害天气的结构预测与应急对策

欧阳首承,谢娜,郝丽萍

期刊论文

Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in

期刊论文

A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus

期刊论文

压水堆熔融物堆内滞留策略：历史回顾与研究展望

马卫民,元一单,Bal Raj Sehgal

期刊论文

New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

期刊论文

Microbial biodegradation of plastics: Challenges, opportunities, and a critical perspective

期刊论文

Arsenic trioxide induced rhabdomyolysis, a rare but severe side effect, in an APL patient: a case report

null

期刊论文

Machine learning in building energy management: A critical review and future directions

期刊论文